| Title | Cortical laminar binding of PET amyloid and tau tracers in Alzheimer disease. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Li Y, Tsui W, Rusinek H, Butler T, Mosconi L, Pirraglia E, Mozley D, Vallabhajosula S, Harada R, Furumoto S, Furukawa K, Arai H, Kudo Y, Okamura N, de Leon MJ |
| Journal | J Nucl Med |
| Volume | 56 |
| Issue | 2 |
| Pagination | 270-3 |
| Date Published | 2015 Feb |
| ISSN | 1535-5667 |
| Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Amyloid beta-Peptides, Biomarkers, Tumor, Carbon Radioisotopes, Cerebral Cortex, Disease Progression, Female, Fluorine Radioisotopes, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurofibrillary Tangles, Positron-Emission Tomography, tau Proteins |
| Abstract | UNLABELLED: Neurofibrillary tau pathology and amyloid β (Aβ) plaques, characteristic lesions of Alzheimer disease (AD), show different neocortical laminar distributions. Neurofibrillary-tangle tau pathology tends to be closer to the gray matter-white matter boundary, whereas Aβ is dispersed throughout the width of the cortical ribbon. METHODS: Using PET radiotracers for tau and Aβ lesions, we developed an image analysis tool to measure the distance of tracer-positive voxels from the gray matter-white matter boundary. We studied 5 AD and 5 healthy subjects with both (18)F-THK5117 (tau) and (11)C-Pittsburgh compound B (Aβ) PET. RESULTS: On average, tau-positive voxels were closer to the white matter than were Aβ-positive voxels. This effect was found for all AD subjects and for all regions, both before and after regionally adjusting for the nonspecific white matter binding of both tracers. The differential laminar pattern was validated through postmortem examination. CONCLUSION: Within cortical lamina, distance measures may be of value in testing PET tracers for their anatomic selectivity. |
| DOI | 10.2967/jnumed.114.149229 |
| Alternate Journal | J Nucl Med |
| PubMed ID | 25572087 |
| PubMed Central ID | PMC4652320 |
| Grant List | R01 AG022374 / AG / NIA NIH HHS / United States M01 RR000096 / RR / NCRR NIH HHS / United States R01 AG035137 / AG / NIA NIH HHS / United States AG035137 / AG / NIA NIH HHS / United States R21 AG032554 / AG / NIA NIH HHS / United States R01 AG013616 / AG / NIA NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States AG013616 / AG / NIA NIH HHS / United States R01 AG012101 / AG / NIA NIH HHS / United States M01 RR010710 / RR / NCRR NIH HHS / United States AG022374 / AG / NIA NIH HHS / United States AG032554 / AG / NIA NIH HHS / United States AG012101 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)