Title | Cerebrovascular reactivity to carbon dioxide in Alzheimer's disease. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Glodzik L, Randall C, Rusinek H, de Leon MJ |
Journal | J Alzheimers Dis |
Volume | 35 |
Issue | 3 |
Pagination | 427-40 |
Date Published | 2013 |
ISSN | 1875-8908 |
Keywords | Aged, Alzheimer Disease, Animals, Brain, Carbon Dioxide, Cardiovascular Diseases, Cognitive Dysfunction, Dementia, Vascular, Disease Models, Animal, Endothelium, Vascular, Humans, Hypercapnia, Image Enhancement, Image Interpretation, Computer-Assisted, Magnetic Resonance Angiography, Neuropsychological Tests, Reference Values, Risk Factors, Vasoconstriction |
Abstract | There is growing evidence that cerebrovascular reactivity to carbon dioxide (CVRCO2) is impaired in Alzheimer's disease (AD). Preclinical and animal studies suggest chronic hypercontractility in brain vessels in AD. We review (a) preclinical studies of mechanisms for impaired CVRCO2 in AD; (b) clinical studies of cerebrovascular function in subjects with AD dementia, mild cognitive impairment (MCI), and normal cognition. Although results of clinical studies are inconclusive, an increasing number of reports reveal an impairment of vascular reactivity to carbon dioxide in subjects with AD, and possibly also in MCI. Thus, CVRCO2 may be an attractive means to detect an early vascular dysfunction in subjects at risk. |
DOI | 10.3233/JAD-122011 |
Alternate Journal | J Alzheimers Dis |
PubMed ID | 23478306 |
PubMed Central ID | PMC3776495 |
Grant List | R01 HL111724 / HL / NHLBI NIH HHS / United States R01 AG013616 / AG / NIA NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States HL111724-01 / HL / NHLBI NIH HHS / United States R01 AG012101 / AG / NIA NIH HHS / United States AG022374 / AG / NIA NIH HHS / United States AG13616 / AG / NIA NIH HHS / United States NIH-NIA AG12101 / AG / NIA NIH HHS / United States R01 AG022374 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)