Title | The bivalent side of the nucleus accumbens. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Levita L, Hare TA, Voss HU, Glover G, Ballon DJ, Casey BJ |
Journal | Neuroimage |
Volume | 44 |
Issue | 3 |
Pagination | 1178-87 |
Date Published | 2009 Feb 01 |
ISSN | 1095-9572 |
Keywords | Acoustic Stimulation, Adult, Auditory Perception, Brain Mapping, Female, Humans, Male, Motivation, Nucleus Accumbens, Reward |
Abstract | An increasing body of evidence suggests that the nucleus accumbens (NAcc) is engaged in both incentive reward processes and in adaptive responses to conditioned and unconditioned aversive stimuli. Yet, it has been argued that NAcc activation to aversive stimuli may be a consequence of the rewarding effects of their termination, i.e., relief. To address this question we used fMRI to delineate brain response to the onset and offset of unpleasant and pleasant auditory stimuli in the absence of learning or motor response. Increased NAcc activity was seen for the onset of both pleasant and unpleasant stimuli. Our results support the expanded bivalent view of NAcc function and call for expansion of current models of NAcc function that are solely focused on reward. |
DOI | 10.1016/j.neuroimage.2008.09.039 |
Alternate Journal | Neuroimage |
PubMed ID | 18976715 |
PubMed Central ID | PMC2659952 |
Grant List | R01 DA018879-05 / DA / NIDA NIH HHS / United States MH079513 / MH / NIMH NIH HHS / United States P50 MH062196 / MH / NIMH NIH HHS / United States P50 MH079513 / MH / NIMH NIH HHS / United States P50 MH062196-050004 / MH / NIMH NIH HHS / United States P50 MH079513-01A1 / MH / NIMH NIH HHS / United States R01 DA018879 / DA / NIDA NIH HHS / United States P50 MH52196 / MH / NIMH NIH HHS / United States |
Related Institute:
MRI Research Institute (MRIRI)