Title | Cardiac quantitative susceptibility mapping (QSM) for heart chamber oxygenation. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Wen Y, Nguyen TD, Liu Z, Spincemaille P, Zhou D, Dimov A, Kee Y, Deh K, Kim J, Weinsaft JW, Wang Y |
Journal | Magn Reson Med |
Volume | 79 |
Issue | 3 |
Pagination | 1545-1552 |
Date Published | 2018 03 |
ISSN | 1522-2594 |
Keywords | Adult, Algorithms, Cardiac Imaging Techniques, Female, Heart, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Oximetry, Young Adult |
Abstract | PURPOSE: To demonstrate the feasibility of in vivo quantitative susceptibility mapping (QSM) in cardiac MRI and to show that mixed-venous oxygen saturation (SvO ) can be measured non-invasively using QSM. METHODS: Electrocardiographic-gated multi-echo 2D gradient echo data were collected at 1.5 T from 14 healthy volunteers during successive breath-holds. Phase wraps and fat chemical shift were removed using a graph-cut-based phase analysis and IDEAL in an iterative approach. The large susceptibility range from air in the lungs to blood in the heart was addressed by using the preconditioning approach in the dipole field inversion. SvO was calculated based on the difference in blood susceptibility between the right ventricle (RV) and left ventricle (LV). Cardiac QSM quality was assessed by two independent readers. RESULTS: Nine out of fourteen volunteers (64%) yielded interpretable cardiac QSM. QSM maps showed strong differential contrast between RV and LV blood with RV blood having higher susceptibility values (291.5 ± 32.4 ppb), which correspond to 78.3 ± 2.3% SvO . CONCLUSION: In vivo cardiac QSM is feasible and can be used to measure SvO , but improvements in data acquisition are needed. Magn Reson Med 79:1545-1552, 2018. © 2017 International Society for Magnetic Resonance in Medicine. |
DOI | 10.1002/mrm.26808 |
Alternate Journal | Magn Reson Med |
PubMed ID | 28653375 |
PubMed Central ID | PMC5743772 |
Grant List | R01 NS072370 / NS / NINDS NIH HHS / United States K23 HL140092 / HL / NHLBI NIH HHS / United States S10 OD021782 / OD / NIH HHS / United States R01 HL128278 / HL / NHLBI NIH HHS / United States R21 EB024366 / EB / NIBIB NIH HHS / United States R01 NS095562 / NS / NINDS NIH HHS / United States R01 NS090464 / NS / NINDS NIH HHS / United States R01 CA181566 / CA / NCI NIH HHS / United States |
Related Institute:
MRI Research Institute (MRIRI)