| Title | Age-related changes in brain: I. Magnetic resonance imaging measures of temporal lobe volumes in normal subjects. |
| Publication Type | Journal Article |
| Year of Publication | 1995 |
| Authors | Convit A, de Leon MJ, Hoptman MJ, Tarshish C, De Santi S, Rusinek H |
| Journal | Psychiatr Q |
| Volume | 66 |
| Issue | 4 |
| Pagination | 343-55 |
| Date Published | 1995 Winter |
| ISSN | 0033-2720 |
| Keywords | Adult, Aged, Aging, Atrophy, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Temporal Lobe |
| Abstract | The volume of temporal lobe structures was examined in twenty-seven older (mean age of 69.2 +/- 8.3 years) and ten younger subjects (mean age of 26.1 +/- 4.1 years) using quantitative magnetic resonance imaging (MRI) methods. Multiple regression analysis, using gender, overall atrophy, and head size as covariates, showed unique contributions of age to variance in both medial and lateral temporal lobe volumes. Temporal lobe subregions that showed the strongest unique age-related reductions were the hippocampus, fusiform gyrus, and parahippocampus. These results suggest age-related reductions in temporal lobe subvolumes. |
| DOI | 10.1007/BF02238754 |
| Alternate Journal | Psychiatr Q |
| PubMed ID | 8584590 |
| Grant List | AG12101 / AG / NIA NIH HHS / United States MH43965 / MH / NIMH NIH HHS / United States P30 G08051 / / PHS HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)