Evaluation of Early Dementia (Mild Cognitive Impairment).

TitleEvaluation of Early Dementia (Mild Cognitive Impairment).
Publication TypeJournal Article
Year of Publication2010
AuthorsOsorio RS, Berti V, Mosconi L, Li Y, Glodzik L, De Santi S, de Leon MJ
JournalPET Clin
Volume5
Issue1
Pagination15-31
Date Published2010 Jan
ISSN1556-8598
Abstract

Early diagnosis of Alzheimer disease (AD) is one of the major challenges for the prevention of this dementia. The pathologic lesions associated with AD develop many years before the clinical manifestations of the disease become evident, during a likely transitional period between normal aging and the appearance of first cognitive symptoms. AD biomarkers are needed not only to reveal these early pathologic changes but also to monitor progression in cognitive and behavioral decline and brain lesions. PET neuroimaging can reliably assess indirect and direct aspects of the molecular biology and neuropathology of AD. This article reviews the use of [18F] 2-fluoro-2-deoxy-D-glucose-PET and amyloid PET imaging in the early detection of AD.

DOI10.1016/j.cpet.2009.12.003
Alternate JournalPET Clin
PubMed ID27157481
Related Institute: 
Brain Health Imaging Institute (BHII)

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065